Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity.

ABSTRACT:

Background

The ISCHEMIA trial (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) postulated that patients with stable coronary artery disease (CAD) and moderate or severe ischemia would benefit from revascularization. We investigated the relationship between severity of CAD and ischemia and trial outcomes, overall and by management strategy.

Methods

In total, 5179 patients with moderate or severe ischemia were randomized to an initial invasive or conservative management strategy. Blinded, core laboratory-interpreted coronary computed tomographic angiography was used to assess anatomic eligibility for randomization. Extent and severity of CAD were classified with the modified Duke Prognostic Index (n=2475, 48%). Ischemia severity wa

SUBMITTER: Reynolds HR 

PROVIDER: S-EPMC8478888 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature