Peptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells.
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ABSTRACT:
SUBMITTER: Seidel RD
PROVIDER: S-EPMC8479091 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Peptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells.
Seidel Ronald D RD Merazga Zohra Z Thapa Dharma Raj DR Soriano Jonathan J Spaulding Emily E Vakkasoglu Ahmet S AS Ruthardt Paige P Bautista Wynona W Quayle Steven N SN Kiener Peter A PA Low Simon S Ross John F JF Cemerski Saso S Suri Anish A Almo Steven C SC Chaparro Rodolfo J RJ
Scientific reports 20210928 1
Targeted pharmacologic activation of antigen-specific (AgS) T cells may bypass limitations inherent in current T cell-based cancer therapies. We describe two immunotherapeutics platforms for selective delivery of costimulatory ligands and peptide-HLA (pHLA) to AgS T cells. We engineered and deployed on these platforms an affinity-attenuated variant of interleukin-2, which selectively expands oligoclonal and polyfunctional AgS T cells in vitro and synergizes with CD80 signals for superior prolife ...[more]
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