Gestational Hormone Concentrations Are Associated With Timing of Delivery in a Fetal Sex-Dependent Manner.

ABSTRACT:

Background

Early delivery remains a significant public health problem that has long-lasting impacts on mother and child. Understanding biological mechanisms underlying timing of labor, including endocrine disruption, can inform prevention efforts.

Methods

Gestational hormones were measured among 976 women in PROTECT, a longitudinal birth cohort in Puerto Rico. We evaluated associations between hormone concentrations at 18 and 26 weeks gestation and gestational age at birth, while assessing effect modification by fetal sex. Exploratory analyses assessed binary outcomes of overall preterm birth (PTB, <37 weeks gestation) and the spontaneous PTB subtype, defined as preterm premature rupture of membranes, spontaneous preterm labor, or both. Multivariable logistic and linear regr

SUBMITTER: Cathey AL 

PROVIDER: S-EPMC8479114 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature