Optimization-based Eukaryotic Genetic Circuit Design (EuGeneCiD) and modeling (EuGeneCiM) tools: Computational approach to synthetic biology.

ABSTRACT: Synthetic biology has the potential to revolutionize the biotech industry and our everyday lives and is already making an impact. Developing synthetic biology applications requires several steps including design and modeling efforts which may be performed by in silico tools. In this work, we have developed two such tools, Eukaryotic Genetic Circuit Design (EuGeneCiD) and Modeling (EuGeneCiM), which use optimization concepts and bioparts including promotors, transcripts, and terminators in designing and modeling genetic circuits. EuGeneCiD and EuGeneCiM preclude problematic designs leading to future synthetic biology application development pipelines. EuGeneCiD and EuGeneCiM are applied to developing 30 basic logic gates as genetic circuit conceptualizations which respond to heavy me

SUBMITTER: Schroeder WL 

PROVIDER: S-EPMC8479143 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature