Pertussis Vaccine Candidate Based on Outer Membrane Vesicles Derived From Biofilm Culture.

ABSTRACT: Outer membrane vesicles (OMV) derived from Bordetella pertussis-the etiologic agent of the resurgent disease called pertussis-are safe and effective in preventing bacterial colonization in the lungs of immunized mice. Vaccine formulations containing those OMV are capable of inducing a mixed Th1/Th2/Th17 profile, but even more interestingly, they may induce a tissue-resident memory immune response. This immune response is recommended for the new generation of pertussis-vaccines that must be developed to overcome the weaknesses of current commercial acellular vaccines (second-generation of pertussis vaccine). The third-generation of pertussis vaccine should also deal with infections caused by bacteria that currently circulate in the population and are phenotypically and genotypically

SUBMITTER: Carriquiriborde F 

PROVIDER: S-EPMC8479151 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature