M6A Classification Combined With Tumor Microenvironment Immune Characteristics Analysis of Bladder Cancer.

ABSTRACT:

Background

Studies have shown that N6-methyl adenosine (m6A) plays an important role in cancer progression; however, the underlying mechanism of m6A modification in tumor microenvironment (TME) cell infiltration of bladder cancer remains unclear. This study aimed to investigate the role of m6A modification in TME cell infiltration of bladder cancer.

Methods

The RNA expression profile and clinical data of bladder cancer were obtained from The Cancer Genome Atlas and Gene Expression Omnibus. We assessed the m6A modification patterns of 664 bladder cancer samples based on 20 m6A regulators through unsupervised clustering analysis and systematically linked m6A modification patterns to TME cell infiltration characteristics. Gene ontology and gene set variation analyses were condu

SUBMITTER: Zhu H 

PROVIDER: S-EPMC8479184 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature