Dose-Response Meta-Analysis on Tooth Loss With the Risk of Cognitive Impairment and Dementia.

ABSTRACT:

Objectives

To quantify the dose-response associations between tooth loss and risk of cognitive impairment and dementia.

Design

Longitudinal studies that examined the association between tooth loss and cognitive function were systematically searched on 6 databases through March 1, 2020. The study adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines. Risk estimates were pooled using random-effects models. The dose-response associations were assessed using generalized least squares spline models.

Setting and participants

Adults from community, institution, outpatient or in-hospital were included in the meta-analysis.

Measures

Cognitive impairment and dementia were defined by neuropsychological tests, diagnosti

SUBMITTER: Qi X 

PROVIDER: S-EPMC8479246 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature