Enterococcus faecalis Glucosamine Metabolism Exacerbates Experimental Colitis.

ABSTRACT:

Background & aims

The inflammatory bowel diseases (IBDs), Crohn's disease and ulcerative colitis, are caused in part by aberrant immune responses to resident intestinal bacteria. Certain dietary components, including carbohydrates, are associated with IBDs and alter intestinal bacterial composition. However, the effects of luminal carbohydrates on the composition and colitogenic potential of intestinal bacteria are incompletely understood. We hypothesize that carbohydrate metabolism by resident proinflammatory intestinal bacteria enhances their growth and worsens intestinal inflammation.

Methods

We colonized germ-free, wild-type, and colitis-susceptible interleukin-10 knockout mice (Il10^-/-) with a consortium of resident intestinal bacterial strains and quantified

SUBMITTER: Fan TJ 

PROVIDER: S-EPMC8479252 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature