Advances in mRNA 5-methylcytosine modifications: Detection, effectors, biological functions, and clinical relevance.

ABSTRACT: 5-methylcytosine (m⁵C) post-transcriptional modifications affect the maturation, stability, and translation of the mRNA molecule. These modifications play an important role in many physiological and pathological processes, including stress response, tumorigenesis, tumor cell migration, embryogenesis, and viral replication. Recently, there has been a better understanding of the biological implications of m⁵C modification owing to the rapid development and optimization of detection technologies, including liquid chromatography-tandem mass spectrometry (LC-MS/MS) and RNA-BisSeq. Further, predictive models (such as PEA-m⁵C, m⁵C-PseDNC, and DeepMRMP) for the identification of potential m⁵C modification sites have also emerged. In this revie

SUBMITTER: Guo G 

PROVIDER: S-EPMC8479277 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature