Real-world safety data for the Pfizer BNT162b2 SARS-CoV-2 vaccine: historical cohort study.

ABSTRACT:

Objective

The Pfizer BNT162b2 vaccine showed a reassuring safety profile in clinical trials, but real-world data are scarce. Bell's palsy, herpes zoster, Guillain-Barré syndrome (GBS) and other neurological complaints in proximity to vaccination have received special public attention. We compared their rates among vaccinated and unvaccinated individuals.

Methods

Individuals ≥16 years vaccinated with at least one dose of BNT162b2 were eligible for this historical cohort study in a health maintenance organization insuring 1.2 million citizens. Each vaccinee was matched to a non-vaccinated control by sex, age, population sector (general Jewish, Arab, ultra-orthodox Jewish) and comorbidities. Diagnosis of Covid-19 before or after vaccination was an exclusion criterion. The outco

SUBMITTER: Shasha D 

PROVIDER: S-EPMC8479307 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature