IRIS-FGM: an integrative single-cell RNA-Seq interpretation system for functional gene module analysis.

ABSTRACT:

Summary

Single-cell RNA-Seq (scRNA-Seq) data is useful in discovering cell heterogeneity and signature genes in specific cell populations in cancer and other complex diseases. Specifically, the investigation of condition-specific functional gene modules (FGM) can help to understand interactive gene networks and complex biological processes in different cell clusters. QUBIC2 is recognized as one of the most efficient and effective biclustering tools for condition-specific FGM identification from scRNA-Seq data. However, its limited availability to a C implementation restricted its application to only a few downstream analysis functionalities. We developed an R package named IRIS-FGM (Integrative scRNA-Seq Interpretation System for Functional Gene Module analysis) to support the inve

SUBMITTER: Chang Y 

PROVIDER: S-EPMC8479672 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature