Associations of genetic variants of miRNA coding regions with pulmonary tuberculosis risk in China

ABSTRACT: Tuberculosis (TB) is the leading cause of death caused by single pathogenic microorganism, Mycobacterium tuberculosis (MTB). The study aims to explore the associations of microRNA (miRNA) single-nucleotide polymorphisms (SNPs) with pulmonary TB (PTB) risk. A population-based case−control study was conducted, and 168 newly diagnosed smear-positive PTB cases and 251 non-TB controls were recruited. SNPs located within miR-27a (rs895819), miR-423 (rs6505162), miR-196a-2 (rs11614913), miR-146a (rs2910164), miR-618 (rs2682818) were selected and MassARRAY® MALDI-TOF System was employed for genotyping. SPSS19.0 was adopted for statistical analysis, non-conditional logistic regression was performed. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were computed to estimate the associations.

SUBMITTER: Zhang M 

PROVIDER: S-EPMC8479703 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature