Hemoprotein Catalyzed Oxygenations: P450s, UPOs, and Progress toward Scalable Reactions.

ABSTRACT: The selective oxygenation of nonactivated carbon atoms is an ongoing synthetic challenge, and biocatalysts, particularly hemoprotein oxygenases, continue to be investigated for their potential, given both their sustainable chemistry credentials and also their superior selectivity. However, issues of stability, activity, and complex reaction requirements often render these biocatalytic oxygenations problematic with respect to scalable industrial processes. A continuing focus on Cytochromes P450 (P450s), which require a reduced nicotinamide cofactor and redox protein partners for electron transport, has now led to better catalysts and processes with a greater understanding of process requirements and limitations for both in vitro and whole-cell systems. However, the discovery and development

SUBMITTER: Grogan G 

PROVIDER: S-EPMC8479775 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature