NK-B cell cross talk induces CXCR5 expression on natural killer cells.

ABSTRACT: B cell follicles (BCFs) in lymph nodes (LNs) are generally exempt of CD8⁺ T and NK cells. African green monkeys (AGMs), a natural host of simian immunodeficiency virus (SIV), display NK cell-mediated viral control in BCF. NK cell migration into BCF in chronically SIVagm-infected AGM is associated with CXCR5⁺ NK cells. We aimed to identify the mechanism leading to CXCR5 expression on NK cells. We show that CXCR5⁺ NK cells in LN were induced following SIVagm infection. CXCR5⁺ NK cells accumulated preferentially in BCF with proliferating B cells. Autologous NK-B cell co-cultures in transwell chambers induced CXCR5⁺ NK cells. Transcriptome analysis of CXCR5⁺ NK cells revealed expression of bcl6 and IL6R. IL-6 induc

SUBMITTER: Rascle P 

PROVIDER: S-EPMC8479784 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature