Inducibility, but not stability, of atrial fibrillation is increased by NOX2 overexpression in mice.

ABSTRACT:

Aims

Gp91-containing NADPH oxidases (NOX2) are a significant source of myocardial superoxide production. An increase in NOX2 activity accompanies atrial fibrillation (AF) induction and electrical remodelling in animal models and predicts incident AF in humans; however, a direct causal role for NOX2 in AF has not been demonstrated. Accordingly, we investigated whether myocardial NOX2 overexpression in mice (NOX2-Tg) is sufficient to generate a favourable substrate for AF and further assessed the effects of atorvastatin, an inhibitor of NOX2, on atrial superoxide production and AF susceptibility.

Methods and results

NOX2-Tg mice showed a 2- to 2.5-fold higher atrial protein content of NOX2 compared with wild-type (WT) controls, which was associated with a significant (twofold)

SUBMITTER: Mighiu AS 

PROVIDER: S-EPMC8479801 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature