Use of menopausal hormone therapy and risk of dementia: nested case-control studies using QResearch and CPRD databases.

ABSTRACT:

Objective

To assess the risks of developing dementia associated with different types and durations of menopausal hormone therapy.

Design

Two nested case-control studies.

Setting

UK general practices contributing to QResearch or the Clinical Practice Research Datalink (CPRD), using all links to hospital, mortality, and social deprivation data.

Participants

118 501 women aged 55 and older with a primary diagnosis of dementia between 1998 and 2020, matched by age, general practice, and index date to 497 416 female controls.

Main outcome measures

Dementia diagnoses from general practice, mortality, and hospital records; odds ratios for menopausal hormone treatments adjusted for demographics, smoking status, alcohol consumption, comorbidities, family history,

SUBMITTER: Vinogradova Y 

PROVIDER: S-EPMC8479814 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature