Genome-wide Association Study Identifies 2 New Loci Associated With Anti-NMDAR Encephalitis.

ABSTRACT:

Background and objectives

To investigate the genetic determinants of the most common type of antibody-mediated autoimmune encephalitis, anti-NMDA receptor (anti-NMDAR) encephalitis.

Methods

We performed a genome-wide association study in 178 patients with anti-NMDAR encephalitis and 590 healthy controls, followed by a colocalization analysis to identify putatively causal genes.

Results

We identified 2 independent risk loci harboring genome-wide significant variants (p < 5 × 10^-8, OR ≥ 2.2), 1 on chromosome 15, harboring only the LRRK1 gene, and 1 on chromosome 11 centered on the ACP2 and NR1H3 genes in a larger region of high linkage disequilibrium. Colocalization signals with expression quantitative trait loci for different brai

SUBMITTER: Tietz AK 

PROVIDER: S-EPMC8479862 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature