Investigating the DNA methylation profile of e-cigarette use.

ABSTRACT:

Background

Little evidence exists on the health effects of e-cigarette use. DNA methylation may serve as a biomarker for exposure and could be predictive of future health risk. We aimed to investigate the DNA methylation profile of e-cigarette use.

Results

Among 117 smokers, 117 non-smokers and 116 non-smoking vapers, we evaluated associations between e-cigarette use and epigenome-wide methylation from saliva. DNA methylation at 7 cytosine-phosphate-guanine sites (CpGs) was associated with e-cigarette use at p < 1 × 10^-5 and none at p < 5.91 × 10^-8. 13 CpGs were associated with smoking at p < 1 × 10^-5 and one at p < 5.91 × 10^-8. CpGs associated with e-cigarette use were largely distinct from those associated with smoking. There was

SUBMITTER: Richmond RC 

PROVIDER: S-EPMC8479883 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature