RKOMICS: an R package for processing mitochondrial minicircle assemblies in population-scale genome projects.

ABSTRACT:

Background

The advent of population-scale genome projects has revolutionized our biological understanding of parasitic protozoa. However, while hundreds to thousands of nuclear genomes of parasitic protozoa have been generated and analyzed, information about the diversity, structure and evolution of their mitochondrial genomes remains fragmentary, mainly because of their extraordinary complexity. Indeed, unicellular flagellates of the order Kinetoplastida contain structurally the most complex mitochondrial genome of all eukaryotes, organized as a giant network of homogeneous maxicircles and heterogeneous minicircles. We recently developed KOMICS, an analysis toolkit that automates the assembly and circularization of the mitochondrial genomes of Kinetoplastid parasites. While this t

SUBMITTER: Geerts M 

PROVIDER: S-EPMC8479924 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature