Oral iron supplementation after antibiotic exposure induces a deleterious recovery of the gut microbiota.

ABSTRACT:

Background

Oral iron supplementation is commonly prescribed for anemia and may play an important role in the gut microbiota recovery of anemic individuals who received antibiotic treatment. This study aims to investigate the effects of iron supplementation on gut microbiota recovery after antibiotics exposure.

Results

Mice were subjected to oral antibiotic treatment with neomycin and metronidazole and were fed diets with different concentrations of iron. The composition of the gut microbiota was followed throughout treatment by 16S rRNA sequencing of DNA extracted from fecal samples. Gut microbiota functions were inferred using PICRUSt2, and short-chain fatty acid concentration in fecal samples was assessed by liquid-chromatography mass spectrometry. Iron supplementation aft

SUBMITTER: Cuisiniere T 

PROVIDER: S-EPMC8480066 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature