Hypocalcemia in COVID-19 is associated with low vitamin D levels and impaired compensatory PTH response.

ABSTRACT:

Background

Hypocalcemia has been identified as a major distinctive feature of COVID-19, predicting poor clinical outcomes. Among the mechanisms underlying this biochemical finding, high prevalence of vitamin D (VD) deficiency in COVID-19 patients reported so far in several studies was advocated. However, robust data in favor of this hypothesis are still lacking. Therefore, aim of our study was to investigate the role of hypovitaminosis D and parathyroid hormone (PTH) levels in the development of hypocalcemia in COVID-19 patients.

Methods

Patients admitted to IRCCS Ospedale San Raffaele for COVID-19 were enrolled in this study, excluding those with comorbidities and therapies influencing calcium and VD metabolism. Serum levels of total calcium (tCa), ionized calcium (Ca²

SUBMITTER: di Filippo L 

PROVIDER: S-EPMC8480127 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature