Multiple Merger Genealogies in Outbreaks of Mycobacterium tuberculosis.

ABSTRACT: The Kingman coalescent and its developments are often considered among the most important advances in population genetics of the last decades. Demographic inference based on coalescent theory has been used to reconstruct the population dynamics and evolutionary history of several species, including Mycobacterium tuberculosis (MTB), an important human pathogen causing tuberculosis. One key assumption of the Kingman coalescent is that the number of descendants of different individuals does not vary strongly, and violating this assumption could lead to severe biases caused by model misspecification. Individual lineages of MTB are expected to vary strongly in reproductive success because 1) MTB is potentially under constant selection due to the pressure of the host immune system and of antibio

SUBMITTER: Menardo F 

PROVIDER: S-EPMC8480183 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature