Minimal residual disease, long-term outcome, and IKZF1 deletions in children and adolescents with Down syndrome and acute lymphocytic leukaemia: a matched cohort study.
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ABSTRACT:
SUBMITTER: Michels N
PROVIDER: S-EPMC8480280 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
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Minimal residual disease, long-term outcome, and IKZF1 deletions in children and adolescents with Down syndrome and acute lymphocytic leukaemia: a matched cohort study.
Michels Naomi N Boer Judith M JM Enshaei Amir A Sutton Rosemary R Heyman Mats M Ebert Sabine S Fiocco Marta M de Groot-Kruseman Hester A HA van der Velden Vincent H J VHJ Barbany Gisela G Escherich Gabriele G Vora Ajay A Trahair Toby T Dalla-Pozza Luciano L Pieters Rob R Zur Stadt Udo U Schmiegelow Kjeld K Moorman Anthony V AV Zwaan C Michel CM den Boer Monique L ML
The Lancet. Haematology 20211001 10
<h4>Background</h4>Patients with Down syndrome and acute lymphocytic leukaemia are at an increased risk of treatment-related mortality and relapse, which is influenced by unfavourable genetic aberrations (eg, IKZF1 deletion). We aimed to investigate the potential underlying effect of Down syndrome versus the effects of adverse cancer genetics on clinical outcome.<h4>Method</h4>Patients (aged 1-23 years) with Down syndrome and acute lymphocytic leukaemia and matched non-Down syndrome patients wit ...[more]
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