The effect of depot medroxyprogesterone acetate on tenofovir alafenamide in rhesus macaques.

ABSTRACT: Prevention of HIV infection and unintended pregnancies are public health priorities. In sub-Saharan Africa, where HIV prevalence is highest, depot medroxyprogesterone acetate (DMPA) is widely used as contraception. Therefore, understanding potential interactions between DMPA and antiretrovirals is critical. Here, we use a macaque model to investigate the effect of DMPA on the pharmacology of the antiretroviral tenofovir alafenamide (TAF). Female rhesus macaques received 30 mg of DMPA (n = 9) or were untreated (n = 9). Macaques received a human equivalent dose of TAF (1.5 mg/kg) orally by gavage. Tenofovir (TFV) and TFV-diphosphate (TFV-DP) were measured in blood, secretions, and tissues over 72 h. The median area under the curve (AUC_0-72h) values for TFV-DP in peripheral blood m

SUBMITTER: Daly MB 

PROVIDER: S-EPMC8480307 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature