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In vivo metal-catalyzed SeCT therapy by a proapoptotic peptide.

ABSTRACT: Selective cell tagging (SeCT) therapy is a strategy for labeling a targeted cell with certain chemical moieties via a catalytic chemical transformation in order to elicit a therapeutic effect. Herein, we report a cancer therapy based on targeted cell surface tagging with proapoptotic peptides (Ac-GGKLFG-X; X = reactive group) that induce apoptosis when attached to the cell surface. Using either Au-catalyzed amidation or Ru-catalyzed alkylation, these proapoptotic peptides showed excellent therapeutic effects both in vitro and in vivo. In particular, co-treatment with proapoptotic peptide and the carrier-Ru complex significantly and synergistically inhibited tumor growth and prolonged survival rate of tumor-bearing mice after only a single injection. This is the first report of Ru catalyst application in vivo, and this approach could be used in SeCT for cancer therapy.

SUBMITTER: Ahmadi P

PROVIDER: S-EPMC8480321 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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<i>In vivo</i> metal-catalyzed SeCT therapy by a proapoptotic peptide.

Ahmadi Peni P Muguruma Kyohei K Chang Tsung-Che TC Tamura Satoru S Tsubokura Kazuki K Egawa Yasuko Y Suzuki Takehiro T Dohmae Naoshi N Nakao Yoichi Y Tanaka Katsunori K

Chemical science 20210902 37

Selective cell tagging (SeCT) therapy is a strategy for labeling a targeted cell with certain chemical moieties <i>via</i> a catalytic chemical transformation in order to elicit a therapeutic effect. Herein, we report a cancer therapy based on targeted cell surface tagging with proapoptotic peptides (Ac-GGKLFG-X; X = reactive group) that induce apoptosis when attached to the cell surface. Using either Au-catalyzed amidation or Ru-catalyzed alkylation, these proapoptotic peptides showed excellent ...[more]

PMID: 34603656

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