Characterization of cardiovascular injury in mice following partial-heart irradiation with clinically relevant dose and fractionation.

ABSTRACT:

Background and purpose

Late cardiac toxicity is a major side effect of radiation therapy (RT) for breast cancer. We developed and characterized a mouse model of radiation-induced heart disease that mimics the dose, fractionation, and beam arrangement of left breast and chest wall RT.

Material and methods

Female wild-type (C57BL6/J) and atherosclerosis-prone apolipoprotein E-deficient (ApoE^-/-) mice (on a C57BL/6J background) on regular chow were treated with 2 Gy × 25 fractions of partial-heart irradiation via opposed tangential beams to the left chest wall. The changes in myocardial perfusion and cardiac function of C57BL/6J mice were examined by single-photon emission computed tomography (SPECT) and echocardiography, respectively. In addition to SPECT and echoca

SUBMITTER: Lee CL 

PROVIDER: S-EPMC8480511 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature