Selenium Derivatives as Promising Therapy for Chagas Disease: In Vitro and In Vivo Studies.

ABSTRACT: Chagas disease is a tropical infection caused by the protozoan parasite Trypanosoma cruzi and a global public health concern. It is a paradigmatic example of a chronic disease without an effective treatment. Current treatments targeting T. cruzi are limited to two obsolete nitroheterocyclic drugs, benznidazole and nifurtimox, which lead to serious drawbacks. Hence, new, more effective, safer, and affordable drugs are urgently needed. Selenium and their derivatives have emerged as an interesting strategy for the treatment of different prozotoan diseases, such as African trypanosomiasis, leishmaniasis, and malaria. In the case of Chagas disease, diverse selenium scaffolds have been reported with antichagasic activity in vitro and in vivo. On the basis of these pre

SUBMITTER: Martin-Escolano R 

PROVIDER: S-EPMC8480776 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature