Immunological investigations of the cerebrospinal fluid in patients with recent onset psychotic disorders: A study protocol.

ABSTRACT:

Background

Though many previous studies have indicated immunological alterations in psychotic disorders, the role and prevalence of neuroinflammation is still unknown. Studies previously investigating immune related biomarkers in the cerebrospinal fluid (CSF) of these patients are mainly small studies on few markers, and many have not compared patients to healthy controls.

Methods

We will conduct a large case-control study including at least 100 patients with recent onset psychotic disorders and 100 sex- and age matched healthy controls. The cases will include patients diagnosed with a psychotic disorder according to ICD-10 (F20/F22-29) within a year prior to inclusion. We will collect both CSF, blood and fecal samples, to gain insight into possible immunological alterations

SUBMITTER: Jeppesen R 

PROVIDER: S-EPMC8480791 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature