Detecting retinal neurodegeneration in people with diabetes: Findings from the UK Biobank.

ABSTRACT:

Importance

Efforts are underway to incorporate retinal neurodegeneration in the diabetic retinopathy severity scale. However, there is no established measure to quantify diabetic retinal neurodegeneration (DRN).

Objective

We compared total retinal, macular retinal nerve fiber layer (mRNFL) and ganglion cell-inner plexiform layer (GC-IPL) thickness among participants with and without diabetes (DM) in a population-based cohort.

Design/setting/participants

Cross-sectional analysis, using the UK Biobank data resource. Separate general linear mixed models (GLMM) were created using DM and glycated hemoglobin as predictor variables for retinal thickness. Sub-analyses included comparing thickness measurements for patients with no/mild diabetic retinopathy (DR) and evaluating

SUBMITTER: Channa R 

PROVIDER: S-EPMC8480885 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature