Potential biomarkers of major depression diagnosis and chronicity.

ABSTRACT:

Background

Molecular biomarkers are promising tools to be routinely used in clinical psychiatry. Among psychiatric diseases, major depression disorder (MDD) has gotten attention due to its growing prevalence and morbidity.

Methods

We tested some peripheral molecular parameters such as serum mature Brain-Derived Neurotrophic Factor (mBDNF), plasma C-Reactive Protein (CRP), serum cortisol (SC), and the salivary Cortisol Awakening Response (CAR), as well as the Pittsburgh sleep quality inventory (PSQI), as part of a multibiomarker panel for potential use in MDD diagnosis and evaluation of disease's chronicity using regression models, and ROC curve.

Results

For diagnosis model, two groups were analyzed: patients in the first episode of major depression (MD: n = 30) and a

SUBMITTER: Galvao ACM 

PROVIDER: S-EPMC8480905 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature