Profiling sensory neuron microenvironment after peripheral and central axon injury reveals key pathways for neural repair.

ABSTRACT: Sensory neurons with cell bodies in dorsal root ganglia (DRG) represent a useful model to study axon regeneration. Whereas regeneration and functional recovery occurs after peripheral nerve injury, spinal cord injury or dorsal root injury is not followed by regenerative outcomes. Regeneration of sensory axons in peripheral nerves is not entirely cell autonomous. Whether the DRG microenvironment influences the different regenerative capacities after injury to peripheral or central axons remains largely unknown. To answer this question, we performed a single-cell transcriptional profiling of mouse DRG in response to peripheral (sciatic nerve crush) and central axon injuries (dorsal root crush and spinal cord injury). Each cell type responded differently to the three types of injuries. All in

SUBMITTER: Avraham O 

PROVIDER: S-EPMC8480984 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature