The Impact of N-Acetylcysteine on Autologous Fat Graft: First-in-Human Pilot Study.

ABSTRACT:

Background

Our goal was to determine whether N-acetylcysteine (NAC) administered to the tumescent solution can reduce oxidative stress and increase autologous fat graft (AFG) viability.

Methods

The study included 15 women with a mean age of 31.8 years (range 23-39 years) who underwent breast asymmetry correction with AFG harvested from both thighs. One thigh was infiltrated with a standard tumescent fluid (control graft) and other with a NAC-enriched tumescent fluid (NAC-treated graft). Each participant had breast MRI imaging before and 6 months after the procedure. Also, adipose tissue samples from each graft were subjected to biochemical analysis, flow cytometric assay and qRT-PCR to determine the markers of oxidative stress, angiogenesis and adipogenesis.

Results

C

SUBMITTER: Pietruski P 

PROVIDER: S-EPMC8481185 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature