Dataset Information

An observational study of breakthrough SARS-CoV-2 Delta variant infections among vaccinated healthcare workers in Vietnam.

ABSTRACT:

Background

Data on breakthrough SARS-CoV-2 Delta variant infections in vaccinated individuals are limited.

Methods

We studied breakthrough infections among Oxford-AstraZeneca vaccinated healthcare workers in an infectious diseases hospital in Vietnam. We collected demographic and clinical data alongside serial PCR testing, measurement of SARS-CoV-2 antibodies, and viral whole-genome sequencing.

Findings

Between 11^th-25^th June 2021 (7-8 weeks after the second dose), 69 staff tested positive for SARS-CoV-2. 62 participated in the study. Most were asymptomatic or mildly symptomatic and all recovered. Twenty-two complete-genome sequences were obtained; all were Delta variant and were phylogenetically distinct from contemporary viruses obtained from the community or from hospital patients admitted prior to the outbreak. Viral loads inferred from Ct values were 251 times higher than in cases infected with the original strain in March/April 2020. Median time from diagnosis to negative PCR was 21 days (range 8-33). Neutralizing antibodies (expressed as percentage of inhibition) measured after the second vaccine dose, or at diagnosis, were lower in cases than in uninfected, fully vaccinated controls (median (IQR): 69.4 (50.7-89.1) vs. 91.3 (79.6-94.9), p=0.005 and 59.4 (32.5-73.1) vs. 91.1 (77.3-94.2), p=0.002). There was no correlation between vaccine-induced neutralizing antibody levels and peak viral loads or the development of symptoms.

Interpretation

Breakthrough Delta variant infections following Oxford-AstraZeneca vaccination may cause asymptomatic or mild disease, but are associated with high viral loads, prolonged PCR positivity and low levels of vaccine-induced neutralizing antibodies. Epidemiological and sequence data suggested ongoing transmission had occurred between fully vaccinated individuals.

Funding

Wellcome and NIH/NIAID.

SUBMITTER: Chau NVV

PROVIDER: S-EPMC8481205 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Publications

An observational study of breakthrough SARS-CoV-2 Delta variant infections among vaccinated healthcare workers in Vietnam.

Chau Nguyen Van Vinh NVV Ngoc Nghiem My NM Nguyet Lam Anh LA Quang Vo Minh VM Ny Nguyen Thi Han NTH Khoa Dao Bach DB Phong Nguyen Thanh NT Toan Le Mau LM Hong Nguyen Thi Thu NTT Tuyen Nguyen Thi Kim NTK Phat Voong Vinh VV Nhu Le Nguyen Truc LNT Truc Nguyen Huynh Thanh NHT That Bui Thi Ton BTT Thao Huynh Phuong HP Thao Tran Nguyen Phuong TNP Vuong Vo Trong VT Tam Tran Thi Thanh TTT Tai Ngo Tan NT Bao Ho The HT Nhung Huynh Thi Kim HTK Minh Nguyen Thi Ngoc NTN Tien Nguyen Thi My NTM Huy Nguy Cam NC Choisy Marc M Man Dinh Nguyen Huy DNH Ty Dinh Thi Bich DTB Anh Nguyen To NT Uyen Le Thi Tam LTT Tu Tran Nguyen Hoang TNH Yen Lam Minh LM Dung Nguyen Thanh NT Hung Le Manh LM Truong Nguyen Thanh NT Thanh Tran Tan TT Thwaites Guy G Tan Le Van LV

EClinicalMedicine 20210930

<h4>Background</h4>Data on breakthrough SARS-CoV-2 Delta variant infections in vaccinated individuals are limited.<h4>Methods</h4>We studied breakthrough infections among Oxford-AstraZeneca vaccinated healthcare workers in an infectious diseases hospital in Vietnam. We collected demographic and clinical data alongside serial PCR testing, measurement of SARS-CoV-2 antibodies, and viral whole-genome sequencing.<h4>Findings</h4>Between 11<sup>th</sup>-25<sup>th</sup> June 2021 (7-8 weeks after the ...[more]

PMID: 34608454

Similar Datasets

Project description:BackgroundDespite the high efficacy of the BNT162b2 messenger RNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rare breakthrough infections have been reported, including infections among health care workers. Data are needed to characterize these infections and define correlates of breakthrough and infectivity.MethodsAt the largest medical center in Israel, we identified breakthrough infections by performing extensive evaluations of health care workers who were symptomatic (including mild symptoms) or had known infection exposure. These evaluations included epidemiologic investigations, repeat reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assays, antigen-detecting rapid diagnostic testing (Ag-RDT), serologic assays, and genomic sequencing. Correlates of breakthrough infection were assessed in a case-control analysis. We matched patients with breakthrough infection who had antibody titers obtained within a week before SARS-CoV-2 detection (peri-infection period) with four to five uninfected controls and used generalized estimating equations to predict the geometric mean titers among cases and controls and the ratio between the titers in the two groups. We also assessed the correlation between neutralizing antibody titers and N gene cycle threshold (Ct) values with respect to infectivity.ResultsAmong 1497 fully vaccinated health care workers for whom RT-PCR data were available, 39 SARS-CoV-2 breakthrough infections were documented. Neutralizing antibody titers in case patients during the peri-infection period were lower than those in matched uninfected controls (case-to-control ratio, 0.361; 95% confidence interval, 0.165 to 0.787). Higher peri-infection neutralizing antibody titers were associated with lower infectivity (higher Ct values). Most breakthrough cases were mild or asymptomatic, although 19% had persistent symptoms (>6 weeks). The B.1.1.7 (alpha) variant was found in 85% of samples tested. A total of 74% of case patients had a high viral load (Ct value, <30) at some point during their infection; however, of these patients, only 17 (59%) had a positive result on concurrent Ag-RDT. No secondary infections were documented.ConclusionsAmong fully vaccinated health care workers, the occurrence of breakthrough infections with SARS-CoV-2 was correlated with neutralizing antibody titers during the peri-infection period. Most breakthrough infections were mild or asymptomatic, although persistent symptoms did occur.

Dataset Information

An observational study of breakthrough SARS-CoV-2 Delta variant infections among vaccinated healthcare workers in Vietnam.

Background

Methods

Findings

Interpretation

Funding

Publications

An observational study of breakthrough SARS-CoV-2 Delta variant infections among vaccinated healthcare workers in Vietnam.

Similar Datasets

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