An observational study of breakthrough SARS-CoV-2 Delta variant infections among vaccinated healthcare workers in Vietnam.

ABSTRACT:

Background

Data on breakthrough SARS-CoV-2 Delta variant infections in vaccinated individuals are limited.

Methods

We studied breakthrough infections among Oxford-AstraZeneca vaccinated healthcare workers in an infectious diseases hospital in Vietnam. We collected demographic and clinical data alongside serial PCR testing, measurement of SARS-CoV-2 antibodies, and viral whole-genome sequencing.

Findings

Between 11^th-25^th June 2021 (7-8 weeks after the second dose), 69 staff tested positive for SARS-CoV-2. 62 participated in the study. Most were asymptomatic or mildly symptomatic and all recovered. Twenty-two complete-genome sequences were obtained; all were Delta variant and were phylogenetically distinct from contemporary viruses obtained from t

SUBMITTER: Chau NVV 

PROVIDER: S-EPMC8481205 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature