EG Coated Stents Exhibit Enhanced Endothelial Wound Healing Characteristics.

ABSTRACT:

Purpose

Despite their widespread use, a significant fraction of coronary stents suffer from in-stent restenosis and stent thrombosis. Stent deployment induces extensive injury to the vascular endothelium. Rapid endothelial wound closure is essential for the success of a stenting procedure. A recent study has demonstrated that the BuMA Supreme® sirolimus-eluting stent exhibits particularly attractive strut coverage characteristics. A unique feature of this stent is the presence of a thin brush layer of poly-butyl methacrylate (PBMA), covalently bonded to the stent's cobalt-chromium frame via electro-grafting (eG™). The present study aimed to determine whether the PBMA coating has an effect on endothelial cell wound healing and stent strut coverage.

Methods

We used an in vitro

SUBMITTER: Rodriguez-Garcia B 

PROVIDER: S-EPMC8481217 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature