¹H, ¹³C, ¹⁵N backbone resonance assignment for the 1-164 construct of human XRCC4.

ABSTRACT: DNA double-strand breaks (DSBs) represent the most cytotoxic DNA lesions, as-if mis- or unrepaired-they can cause cell death or lead to genome instability, which in turn can cause cancer. DSBs are repaired by two major pathways termed homologous recombination and non-homologous end-joining (NHEJ). NHEJ is responsible for repairing the vast majority of DSBs arising in human cells. Defects in NHEJ factors are also associated with microcephaly, primordial dwarfism and immune deficiencies. One of the key proteins important for mediating NHEJ is XRCC4. XRCC4 is a dimer, with the dimer interface mediated by an extended coiled-coil. The N-terminal head domain forms a mixed alpha-beta globular structure. Numerous factors interact with the C-terminus of the coiled-coil domain, which is also associa

SUBMITTER: Cabello-Lobato MJ 

PROVIDER: S-EPMC8481219 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature