Prevention of Ischemic Myocardial Contracture Through Hemodynamically Controlled DCD.

ABSTRACT:

Purpose

Ischemic myocardial contracture (IMC) or "stone heart" is a condition with rapid onset following circulatory death. It inhibits transplantability of hearts donated upon circulatory death (DCD). We investigate the effectiveness of hemodynamic normalization upon withdrawal of life-sustaining therapy (WLST) in a large-animal controlled DCD model, with the hypothesis that reduction in cardiac work delays the onset of IMC.

Methods

A large-animal study was conducted comprising of a control group ([Formula: see text]) receiving no therapy upon WLST, and a test group ([Formula: see text]) subjected to a protocol for fully automated computer-controlled hemodynamic drug administration. Onset of IMC within 1 h following circulatory death defined the primary end-point. Cardiac w

SUBMITTER: Wahlquist Y 

PROVIDER: S-EPMC8481220 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature