Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography.

ABSTRACT: The purpose of this study was to assess the diagnostic value of multifrequency MR elastography for grading necro-inflammation in the liver. Fifty participants with chronic hepatitis B or C were recruited for this institutional review board-approved study. Their liver was examined with multifrequency MR elastography. The storage, shear and loss moduli, and the damping ratio were measured at 56 Hz. The multifrequency wave dispersion coefficient of the shear modulus was calculated. The measurements were compared to reference markers of necro-inflammation and fibrosis with Spearman correlations and multiple regression analysis. Diagnostic accuracy was assessed. At multiple regression analysis, necro-inflammation was the only determinant of the multifrequency dispersion coefficient, whereas fib

SUBMITTER: Garteiser P 

PROVIDER: S-EPMC8481240 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature