A novel insight into differential expression profiles of sporadic cerebral cavernous malformation patients with different symptoms.

ABSTRACT: Cerebral cavernous malformation (CCM) is a vascular lesion of the central nervous system that may lead to distinct symptoms among patients including cerebral hemorrhages, epileptic seizures, focal neurologic deficits, and/or headaches. Disease-related mutations were identified previously in one of the three CCM genes: CCM1, CCM2, and CCM3. However, the rate of these mutations in sporadic cases is relatively low, and new studies report that mutations in CCM genes may not be sufficient to initiate the lesions. Despite the growing body of research on CCM, the underlying molecular mechanism has remained largely elusive. In order to provide a novel insight considering the specific manifested symptoms, CCM patients were classified into two groups (as Epilepsy and Hemorrhage). Since the studied p

SUBMITTER: Eren Gozel H 

PROVIDER: S-EPMC8481309 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature