The Concentration of Large Extracellular Vesicles Differentiates Early Septic Shock From Infection.

ABSTRACT: Septic shock represents a subset of sepsis with severe physiological aberrations and a higher mortality rate than sepsis alone. Currently, the laboratory tools which can be used to identify the state of septic shock are limited. In pre-clinical studies, extracellular vesicles (EVs), especially large EVs (lEVs), have been demonstrated a role as functional inflammatory mediators of sepsis. However, its longitudinal trend during the disease course has not been explored. In this study, the quantities and subtypes of plasma-derived lEVs were longitudinally compared between patients with septic shock (n = 21) and non-sepsis infection (n = 9), who presented within 48 h of their symptom onset. Blood specimens were collected for seven consecutive days after hospital admission. lEVs qu

SUBMITTER: Monnamorn L 

PROVIDER: S-EPMC8481381 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature