Proteomic and molecular dynamic investigations of PTM-induced structural fluctuations in breast and ovarian cancer.

ABSTRACT: Post-translational processing leads to conformational changes in protein structure that modulate molecular functions and change the signature of metabolic transformations and immune responses. Some post-translational modifications (PTMs), such as phosphorylation and acetylation, are strongly related to oncogenic processes and malignancy. This study investigated a PTM pattern in patients with gender-specific ovarian or breast cancer. Proteomic profiling and analysis of cancer-specific PTM patterns were performed using high-resolution UPLC-MS/MS. Structural analysis, topology, and stability of PTMs associated with sex-specific cancers were analyzed using molecular dynamics modeling. We identified highly specific PTMs, of which 12 modified peptides from eight distinct proteins derived from pa

SUBMITTER: Tikhonov D 

PROVIDER: S-EPMC8481388 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature