Carbamoyl phosphate and its substitutes for the uracil synthesis in origins of life scenarios.

ABSTRACT: The first step of pyrimidine synthesis along the orotate pathway is studied to test the hypothesis of geochemical continuity of protometabolic pathways at the origins of life. Carbamoyl phosphate (CP) is the first high-energy building block that intervenes in the in vivo synthesis of the uracil ring of UMP. Thus, the likelihood of its occurrence in prebiotic conditions is investigated herein. The evolution of carbamoyl phosphate in water and in ammonia aqueous solutions without enzymes was characterised using ATR-IR, ³¹P and ¹³C spectroscopies. Carbamoyl phosphate initially appears stable in water at ambient conditions before transforming to cyanate and carbamate/hydrogenocarbonate species within a matter of hours. Cyanate, less labile than CP, remains a potential car

SUBMITTER: Ter-Ovanessian LMP 

PROVIDER: S-EPMC8481487 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature