Ontology highlight
ABSTRACT:
SUBMITTER: Kamagata K
PROVIDER: S-EPMC8481498 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Kamagata Kiyoto K Iwaki Nanako N Hazra Milan Kumar MK Kanbayashi Saori S Banerjee Trishit T Chiba Rika R Sakomoto Seiji S Gaudon Virginie V Castaing Bertrand B Takahashi Hiroto H Kimura Michiko M Oikawa Hiroyuki H Takahashi Satoshi S Levy Yaakov Y
Scientific reports 20210929 1
Despite the continuous discovery of host and guest proteins in membraneless organelles, complex host-guest interactions hinder the understanding of the molecular grammar governing liquid-liquid phase separation. In this study, we characterized the localization and dynamic properties of guest proteins in liquid droplets using single-molecule fluorescence microscopy. Eighteen guest proteins of different sizes, structures, and oligomeric states were examined in host p53 liquid droplets. Recruitment ...[more]