Catecholamine Surges Cause Cardiomyocyte Necroptosis via a RIPK1-RIPK3-Dependent Pathway in Mice.

ABSTRACT: Background: Catecholamine surges and resultant excessive β-adrenergic stimulation occur in a broad spectrum of diseases. Excessive β-adrenergic stimulation causes cardiomyocyte necrosis, but the underlying mechanism remains obscure. Necroptosis, a major form of regulated necrosis mediated by RIPK3-centered pathways, is implicated in heart failure; however, it remains unknown whether excessive β-adrenergic stimulation-induced cardiac injury involves necroptosis. Hence, we conducted the present study to address these critical gaps. Methods and Results: Two consecutive daily injections of isoproterenol (ISO; 85 mg/kg, s.c.) or saline were administered to adult mixed-sex mice. At 24 h after the second ISO injection, cardiac area with Evans blue dye (EBD) uptake and myocardial pro

SUBMITTER: Wu P 

PROVIDER: S-EPMC8481609 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature