RNase A Inhibits Formation of Neutrophil Extracellular Traps in Subarachnoid Hemorrhage.

ABSTRACT: Background: Subarachnoid hemorrhage (SAH) caused by rupture of an intracranial aneurysm, is a life-threatening emergency that is associated with substantial morbidity and mortality. Emerging evidence suggests involvement of the innate immune response in secondary brain injury, and a potential role of neutrophil extracellular traps (NETs) for SAH-associated neuroinflammation. In this study, we investigated the spatiotemporal patterns of NETs in SAH and the potential role of the RNase A (the bovine equivalent to human RNase 1) application on NET burden. Methods: A total number of n=81 male C57Bl/6 mice were operated utilizing a filament perforation model to induce SAH, and Sham operation was performed for the corresponding control groups. To confirm the bleeding and excl

SUBMITTER: Fruh A 

PROVIDER: S-EPMC8481772 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature