Cross-Disorder Genomics Data Analysis Elucidates a Shared Genetic Basis Between Major Depression and Osteoarthritis Pain.

ABSTRACT: Osteoarthritis (OA) and major depression (MD) are two debilitating disorders that frequently co-occur and affect millions of the elderly each year. Despite the greater symptom severity, poorer clinical outcomes, and increased mortality of the comorbid conditions, we have a limited understanding of their etiologic relationships. In this study, we conducted the first cross-disorder investigations of OA and MD, using genome-wide association data representing over 247K cases and 475K controls. Along with significant positive genome-wide genetic correlations (r _g = 0.299 ± 0.026, p = 9.10 × 10^-31), Mendelian randomization (MR) analysis identified a bidirectional causal effect between OA and MD (β_{OA → MD} = 0.09, SE = 0.02, z

SUBMITTER: Barowsky S 

PROVIDER: S-EPMC8481820 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature