The Clinical Significance of Mesenteric Lymphocytes in Human Colorectal Cancer.

ABSTRACT:

Objective

The mesentery is a potential site of residual tumor in patients with colorectal cancer (CRC). However, the mesenteric immune microenvironment remains unclear. In this study, we investigated the immune landscape of the mesentery, particularly the role of lymphocytes and its association with the clinicopathological characteristics of CRC.

Methods

Flow cytometry was used to detect lymphocytes in the paired mesenteric tissue specimens adjacent to the colorectal tumors and normal mesenteric tissue specimens 10 cm away from the colorectal tumor edge and preoperative peripheral blood samples obtained from patients with CRC who underwent surgery. T-distributed stochastic neighbor embedding was utilized to analyze multiparameter flow cytometry data. Multiplex immunohistoche

SUBMITTER: Wu ZX 

PROVIDER: S-EPMC8481834 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature