Unsupervised mobile cognitive testing for use in preclinical Alzheimer's disease.

ABSTRACT:

Introduction

Unsupervised digital cognitive testing is an appealing means to capture subtle cognitive decline in preclinical Alzheimer's disease (AD). Here, we describe development, feasibility, and validity of the Boston Remote Assessment for Neurocognitive Health (BRANCH) against in-person cognitive testing and amyloid/tau burden.

Methods

BRANCH is web-based, self-guided, and assesses memory processes vulnerable in AD. Clinically normal participants (n = 234; aged 50-89) completed BRANCH; a subset underwent in-person cognitive testing and positron emission tomography imaging. Mean accuracy across BRANCH tests (Categories, Face-Name-Occupation, Groceries, Signs) was calculated.

Results

BRANCH was feasible to complete on participants' own devices (primarily smartphone

SUBMITTER: Papp KV 

PROVIDER: S-EPMC8481881 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature