Locoregional therapy in de novo metastatic breast cancer: Systemic review and meta-analysis.

ABSTRACT:

Background

Locoregional therapy (LRT) in de novo metastatic disease is controversial with inconsistent results from randomized control trials (RCTs).

Methods

RCTs comparing LRT and systemic therapy to standard therapy alone in de novo metastatic breast cancer were identified. Hazard ratios (HRs) and their associated 95% confidence intervals (CIs) were computed and pooled in a meta-analysis using generic inverse variance. Overall survival (OS) and time to locoregional progression data were extracted for the intention to treat (ITT) population. Data on OS for pre-specified subgroups defined by tumor subtype and by site of metastases were also extracted.

Results

Analyses included 4 trials comprising 970 patients. LRT included standard surgery to the primary breast tumor

SUBMITTER: Reinhorn D 

PROVIDER: S-EPMC8481908 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature