On Deep Landscape Exploration of COVID-19 Patients Cells and Severity Markers.

ABSTRACT: COVID-19 is a disease with a spectrum of clinical responses ranging from moderate to critical. To study and control its effects, a large number of researchers are focused on two substantial aims. On the one hand, the discovery of diverse biomarkers to classify and potentially anticipate the disease severity of patients. These biomarkers could serve as a medical criterion to prioritize attention to those patients with higher prone to severe responses. On the other hand, understanding how the immune system orchestrates its responses in this spectrum of disease severities is a fundamental issue required to design new and optimized therapeutic strategies. In this work, using single-cell RNAseq of bronchoalveolar lavage fluid of nine patients with COVID-19 and three healthy controls, we contrib

SUBMITTER: Vazquez-Jimenez A 

PROVIDER: S-EPMC8481922 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature