Transcriptional and translational landscape of Candida auris in response to caspofungin.

ABSTRACT: Candida auris has emerged as a serious worldwide threat by causing opportunistic infections that are frequently resistant to one or more conventional antifungal medications resulting in high mortality rates. Against this backdrop, health warnings around the world have focused efforts on understanding C. auris fungal biology and effective prevention and treatment approaches to combat this fungus. To date, there is little information about the differentially expressed genes when this fungus is treated with conventional antifungals, and caspofungin is a standard echinocandin deployed in the therapy against C. auris. In this work, we treated two distinct strains of C. auris for 24 h with caspofungin, and the cellular responses were evaluated at the morphological, tr

SUBMITTER: Zamith-Miranda D 

PROVIDER: S-EPMC8481930 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature